Neuroprotection after infection-sensitized neonatal hypoxic-ischemic brain injury
نویسندگان
چکیده
منابع مشابه
Neuroprotection after infection-sensitized neonatal hypoxic-ischemic brain injury
s of the 51st Workshop for Pediatric Research 51st Workshop for Pediatric Research
متن کاملHypothermia is not neuroprotective after infection-sensitized neonatal hypoxic-ischemic brain injury.
BACKGROUND Therapeutic hypothermia (HT) is the standard treatment after perinatal hypoxic-ischemic (HI) injury. Infection increases vulnerability to HI injury, but the effect of HT on lipopolysaccharide (LPS) sensitized HI brain injury is unknown. DESIGN/METHODS P7 rat pups were injected either with vehicle or LPS, and after a 4h delay they were exposed to left carotid ligation followed by gl...
متن کاملPharmacological Neuroprotection after Perinatal Hypoxic-Ischemic Brain Injury
Perinatal hypoxia-ischemia (HI) is an important cause of neonatal brain injury. Recent progress in the search for neuroprotective compounds has provided us with several promising drugs to reduce perinatal HI-induced brain injury. In the early stage (first 6 hours after birth) therapies are concentrated on prevention of the production of reactive oxygen species or free radicals (xanthine-oxidase...
متن کاملOsteopontin enhances endogenous repair after neonatal hypoxic-ischemic brain injury.
BACKGROUND AND PURPOSE Hypoxic-ischemic (HI) brain injury is a frequent cause of perinatal morbidity and mortality with limited therapeutic options. To identify molecules important for cerebral damage and repair, we investigated the growth factor-related gene expression profile after neonatal cerebral HI. We identified osteopontin (OPN) as the most highly upregulated factor early after HI. We t...
متن کاملThe role of pentoxifylline on neuroprotection in neonatal rat model of hypoxic ischemic brain injury
Despite important progress in obstetric and neonatal care hypoxic-ischemic encephalopathy (HIE) during gestation and perinatal period are common causes of neonatal brain damage which are frequently associated with neurodevelopmental disorders, including cerebral palsy, epilepsy, memory deficits, learning disabilities, and other cognitive impairments [1-3]. Incidence is 1 to 2 per 1000 live birt...
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ژورنال
عنوان ژورنال: Molecular and Cellular Pediatrics
سال: 2015
ISSN: 2194-7791
DOI: 10.1186/2194-7791-2-s1-a11